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Vitamin D and COVID-19

VITAMIN D AND VIRAL INFECTIONS

Vitamin D plays a modulatory role in the immune system, as it increases the secretion of numerous antiviral peptides to support innate immunity and can also induce autophagy in response to viral substances.

Additionally, vitamin D has been shown to reduce the risk of microbial infections and mortality through various pathways. When an individual acquires the common cold, for example, vitamin D can act as a physical barrier against the infection, or act through cellular natural and/or adaptive immunity mechanisms to reduce the risk of infection.

Between the years 2007 and 2020, several meta-analyses of randomized controlled trials supported the hypothesis that vitamin D exerts protective effects against acute respiratory infections and that a deficiency of vitamin D within the serum can in fact increase the risk of community-acquired pneumonia.

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